Whole Mitochondrial Gene Sequencing

Mitochondria (MT) ia the powerhouse of a cell. That play an important role in major cellular operation. This organelle orchestrate the energy homeostasis through oxidative phosphorylation (OXPHOS), cell death, calcium levels regulation, lipid homeostasis, and metabolic cell signalling that results in more distinct conditions in potential multi organ tissues such as brain & cardiac, that have high energy demands. Whole mitochondrial DNA sequencing is an NGS based process that detects pathogenic point mutations and single large-scale deletions with heteroplasmy levels in the mtDNA that contribute to mitochondrial dysfunction. This technique enables comprehensive accurate detection and analysis of mitochondrial disease-associated variants.